Biomaterial Database

Decreased tubular reabsorption of zinc in rats with chronic uremia. 1996

T K Young, and S C Wang, and S M Chen, and C C Shi

Department of Physiology, School of Life Sciences, National Yang-Ming University, Taipei, Taiwan, The Republic of China.

Effect of chronic uremia on tubular reabsorption of zinc was studied in rats with different zinc nutritional status. Using inulin clearance to represent glomerular filtration rate and plasma ultrafiltrate to imitate glomerular filtrate in vivo, the glomerular filtered load of zinc was estimated in each rat. The amount of tubular reabsorption of zinc equals the amount of zinc filtered minus the amount of zinc excreted into the urine. Proportion of filtered zinc excreted was estimated to be 2.8-8.7% in control rats and 17.3-29.8% in uremic rats induced by five-sixths nephrectomy. Similarly, proportion of filtered zinc reabsorption decreased significantly from 91.3-97.3% in control rats to 70.1-82.7% in uremic rats. Zinc deficiency increased fractional reabsorption of zinc in uremic rats but not in control rats. Fractional excretion of zinc correlated with both urine flow rate and urinary excretion of protein. The results suggest that uremia toxins may influence tubular reabsorption of zinc even in the presence of renal adaptation to zinc deficiency.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014511	Uremia	A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.	Uremias
D015032	Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
D017207	Rats, Sprague-Dawley	A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.	Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus