Biomaterial Database

Treatment of factor VII deficiency with recombinant factor VIIa. 1996

K A Bauer

Hematology-Oncology Section, Department of Medicine, Brockton-West Roxbury, Harvard Medical School, Boston, Masschusetts, USA.

Factor VII deficiency is a relatively infrequent hereditary bleeding disorder. Recombinant factor VIIa has been used to treat patients with factor VII deficiency with bleeding episodes or undergoing surgery. The drug has shown a high efficacy rate and will provide factor VII-deficient patients with a therapeutic agent that is not derived from human plasma.

UI	MeSH Term	Description	Entries
D011994	Recombinant Proteins	Proteins prepared by recombinant DNA technology.	Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D005168	Factor VII Deficiency	An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.	Hypoproconvertinemia,Deficiency, Factor 7,Deficiency, Factor Seven,Deficiency, Factor VII,Factor 7 Deficiency,Deficiencies, Factor 7,Deficiencies, Factor Seven,Deficiencies, Factor VII,Factor 7 Deficiencies,Factor Seven Deficiencies,Factor Seven Deficiency,Factor VII Deficiencies,Hypoproconvertinemias
D006470	Hemorrhage	Bleeding or escape of blood from a vessel.	Bleeding,Hemorrhages
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015942	Factor VIIa	Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.	Coagulation Factor VIIa,Factor VII, Activated,Blood Coagulation Factor VII, Activated,Factor 7A,Factor Seven A,Activated Factor VII,Factor VIIa, Coagulation