Biomaterial Database

Kinetics of n-butyl alcohol and m-xylene in blood during single and combined inhalation exposure in rats. 1995

R Swiercz, and Z Korsak, and K Rydzynski

Department of Toxicology Evaluation, The Nofer Institute of Occupational Medicine, Lodz, Poland.

The levels of m-xylene and n-butyl alcohol in blood of rats during single and combined inhalation exposure to m-xylene and n-butyl alcohol at the concentrations of 100 + 100 ppm were investigated. We found that levels of n-butyl alcohol and m-xylene in blood of animals during single exposure did not differ as compared to coexposure. It has been shown that less than additive neurotoxic and irritating respiratory tract effects of m-xylene and n-butyl alcohol mixture, observed earlier under acute and subchronic inhalation study, cannot be explained by their metabolic interaction.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000280	Administration, Inhalation	The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.	Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000440	Butanols	Isomeric forms and derivatives of butanol (C4H9OH).	Alcohols, Butyl,Butanol,Butylhydroxides,Hydroxybutanes,Butyl Alcohols
D000704	Analysis of Variance	A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.	ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014992	Xylenes	A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)	Dimethylbenzenes,Xylene
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D020001	1-Butanol	A four carbon linear hydrocarbon that has a hydroxy group at position 1.	n-Butanol,Butyl Alcohol,n-Butyl Alcohol,1 Butanol,Alcohol, Butyl,Alcohol, n-Butyl,n Butanol,n Butyl Alcohol