BIOMAT Database Logo BIOMAT Database Logo

15-deoxyspergualin downregulates MHC class II antigen expression and cell migration in models of graft-versus-host and host-versus-graft disease. 1996

A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D007421 Intestine, Small The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM. Small Intestine,Intestines, Small,Small Intestines
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008297 Male Males
D011917 Rats, Inbred Lew An inbred strain of rat that is used in BIOMEDICAL RESEARCH. Rats, Inbred Lewis,Rats, Lew,Inbred Lew Rat,Inbred Lew Rats,Inbred Lewis Rats,Lew Rat,Lew Rat, Inbred,Lew Rats,Lew Rats, Inbred,Lewis Rats, Inbred,Rat, Inbred Lew,Rat, Lew
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D005802 Genes, MHC Class II Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and include H-2M, I-A, and I-E loci in mice. Class II Genes,Genes, Class II,Genes, HLA Class II,MHC Class II Genes,Class II Gene,Gene, Class II
D006086 Graft vs Host Disease The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION. Graft-Versus-Host Disease,Homologous Wasting Disease,Runt Disease,Graft-vs-Host Disease,Disease, Graft-Versus-Host,Disease, Graft-vs-Host,Disease, Homologous Wasting,Disease, Runt,Diseases, Graft-Versus-Host,Diseases, Graft-vs-Host,Graft Versus Host Disease,Graft-Versus-Host Diseases,Graft-vs-Host Diseases

Related Publications

A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Epithelial class II antigen expression in cutaneous graft-versus-host disease.
August 1987, Transplantation,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
[Preclinical results with 15-deoxyspergualin in experimental graft versus host disease].
February 1988, Immunitat und Infektion,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Expression of MHC class II antigens on bile duct epithelium in experimental graft versus host disease.
June 1985, Clinical and experimental immunology,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Class II antigen expression by keratinocytes and enterocytes--an early feature of graft-versus-host-disease.
September 1988, Transplantation,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Deoxyspergualin in lethal murine graft-versus-host disease.
March 1991, Transplantation,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.
November 2019, Immunity,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Effects of spergualin and 15-deoxyspergualin on the development of graft-versus-host disease in mice.
August 1987, Transplantation proceedings,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Effect of deoxyspergualin on graft-versus-host disease and graft- versus-leukemia in mice.
May 1996, Bone marrow transplantation,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Class II antigen induction in the liver of rats with graft-versus-host disease.
August 1984, Transplantation,
A M Waaga, and F Fändrich, and M Krzymanski, and V Eckstein, and C Herwartz, and W Muller-Ruchholtz, and M E Russell
Cyclosporine-induced syngeneic graft-versus-host disease: recognition of self MHC class II antigens in vivo.
February 1993, Transplantation proceedings,
Copied contents to your clipboard!