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4-Methylcyclophosphamide, an analogue of the antitumour agent cyclophosphamide, exists in cis and trans forms, each of which comprises a pair of optical isomers. The extents of metabolism by rat liver microsomes during 20 min were compared for the four steroisomers incubated separately, and for the racemic cis and trans-derivatives in admixture, using mass spectrometry and gas chromatography respectively. In comparative antitumour tests against the ADJ/PC6 plasma cell tumour in mice, the racemic cis and trans forms of 4- and 6-methylcyclophosphamide had similar therapeutic indices. The four stereoisomers of 4-methylcyclophosphamide exhibited an approx. two-fold range in therapeutic index so that there was no marked effect on either metabolism or antitumour activity occasioned by change of configuration either at C-4 or at phosphorus.
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
November 1975,
Cancer research,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
July 1982,
Journal of steroid biochemistry,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
July 1964,
Journal of lipid research,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
December 1975,
The Journal of nutrition,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
August 1966,
The Biochemical journal,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
February 2002,
British journal of cancer,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
May 1974,
Cancer research,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
December 1946,
Journal of the Chemical Society,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
September 2001,
Anesthesiology,
P B Farmer, and
M Jarman, and
T Facchinetti, and
K Pankiewicz, and
W J Stec
January 1979,
Journal of agricultural and food chemistry,
