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Mouse epidermal homogenates contain an inducible aryl hydrocarbon hydroxylase (AHH) complex that catalyzes the formation of benzo(a)pyrene-7,8-dihydrodiol from benzo(a)pyrene (BP) as assessed by high pressure liquid chromatography (HPLC). 5,6-Benzoflavone (5,6-BF), 7,8-benzoflavone (7,8-BF) and 17-beta-estradiol decreased and butylated hydroxytoluene (BHT) enhanced oxidative metabolism of BP when added in vitro. Epoxide hydrase activity (hydration of benzo(a)pyrene-4,5-epoxide) (BP-4,5-epoxide) was enhanced by 17-beta-estradiol, 5,6-BF, and 7,8-BF. BHT exhibited no significant effect and 1,2-epoxy-3,3,3-trichloropropane (TCPO) inhibited hydrase activity. The capacity of epidermal homogenates to catalyze the covalent binding of BP to DNA indicated that addition of both 5,6-BF and 7,8-BF decreased binding. BHT and TCPO did not significantly affect DNA-binding.
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
January 1978,
Advances in chromatography,
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
January 1977,
Cancer research,
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
August 1988,
Biochemical and biophysical research communications,
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
April 1974,
Science (New York, N.Y.),
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
September 1976,
Journal - Association of Official Analytical Chemists,
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
July 1987,
Cancer research,
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
May 1985,
Carcinogenesis,
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
July 1985,
Cancer research,
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
June 1978,
Bulletin of environmental contamination and toxicology,
D L Berry, and
W R Bracken, and
T J Slaga, and
N M Wilson, and
S G Butty, and
M R Juchau
November 1974,
Proceedings of the National Academy of Sciences of the United States of America,
