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An integrated YAC map of the human X chromosome. 1996
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
Max-Planck-Institut für Molekulare Genetik, Berlin, Germany. roest@mpimg-berlin-dahlem.mpg.de
The human X chromosome is associated with a large number of disease phenotypes, principally because of its unique mode of inheritance that tends to reveal all recessive disorders in males. With the longer term goal of identifying and characterizing most of these genes, we have adopted a chromosome-wide strategy to establish a YAC contig map. We have performed > 3250 inter Alu-PCR product hybridizations to identify overlaps between YAC clones. Positional information associated with many of these YAC clones has been derived from our Reference Library Database and a variety of other public sources. We have constructed a YAC contig map of the X chromosome covering 125 Mb of DNA in 25 contigs and containing 906 YAC clones. These contigs have been verified extensively by FISH and by gel and hybridization fingerprinting techniques. This independently derived map exceeds the coverage of recently reported X chromosome maps built as part of whole-genome YAC maps.
Related Publications
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
May 1994,
Human molecular genetics,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
July 1997,
Genome research,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
June 2002,
Animal genetics,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
November 1995,
Genome research,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
December 1996,
Genomics,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
September 1995,
Nature,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
January 1997,
Mammalian genome : official journal of the International Mammalian Genome Society,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
June 1999,
Genomics,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
September 1995,
Nature,
H Roest Crollius, and
M T Ross, and
A Grigoriev, and
C J Knights, and
E Holloway, and
J Misfud, and
K Li, and
M Playford, and
S G Gregory, and
S J Humphray, and
A J Coffey, and
C G See, and
S Marsh, and
R Vatcheva, and
J Kumlien, and
T Labella, and
V Lam, and
K H Rak, and
K Todd, and
R Mott, and
D Graeser, and
G Rappold, and
G Zehetner, and
A Poustka, and
D R Bentley, and
A P Monaco, and
H Lehrach
September 1995,
Nature,
