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The importance of early diagnois and treatment of congenital hypothyroidism has been well established, and several screening programs have been undertaken to detect neonates with this disorder by measurement of concentrations of thyrotropin or thyroxine in the serum. However, measurement of either hormone alone may fail to identify all affected patients. Accordingly, we have established a simultaneous double-antibody, dual-isotope radioimmunoassay for both. Sensitivity, slope, analytical recovery, and precision characteristics of the simultaneous assay do not differ from those of each assay performed separately. Values for the two analyses in the single and simultaneous assays correlate well (r = 0.951 for thyroxine, 0.983 for thyrotropin). This assay system permits determination of both hormones within 72 h after specimen collection and thus should allow more rapid evaluation, diagnosis, and treatment of infants with congenital hypothyroidism.
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
September 1965,
The Journal of clinical endocrinology and metabolism,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
April 1965,
Metabolism: clinical and experimental,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
March 1978,
Clinical chemistry,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
March 1972,
Biochemical and biophysical research communications,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
March 1976,
Acta endocrinologica,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
September 1972,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
October 1974,
Clinical endocrinology,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
December 1973,
Clinica chimica acta; international journal of clinical chemistry,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
May 1974,
The Journal of endocrinology,
M K Bluett, and
E O Reiter, and
G E Duckett, and
A W Root
March 1981,
Annals of clinical biochemistry,
