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The aim of this study was to investigate the possible involvement of the histamine H3 receptor in control of exocrine pancreatic secretion from the guinea-pig. In in vitro experiments, the H3 receptor agonist (R)-alpha-methylhistamine (0.01-10 microM) elicited a concentration-dependent decrease in the release of alpha-amylase. (R)-alpha-Methylhistamine concentrations above 10 microM evoked a concentration-dependent increase in alpha-amylase secretion. Application of mepyramine (1 microM) partially blocked this increase. The H3 receptor antagonist thioperanide (1 microM) blocked the effects of (R)-alpha-methylhistamine below 10 microM. Histamine and (R)-alpha-methylhistamine attenuated both protein release elicited during electrical-field stimulation and the release of tritiated choline, and these effects were reversed by thioperamide. In an in vivo study, (R)-alpha-methylhistamine increased juice secretion and total protein content of the juice by 40%. Histamine H1 and H2 receptor antagonists blocked this increase and uncovered an attenuation of the secretory parameters (juice flow 28%, total protein content 44%). This attenuation was blocked by thioperamide. These observations suggest that stimulation of the histamine H3 receptor in the pancreas results in a decreased fluid and enzyme release by inhibition of acetylcholine release from intrinsic pancreatic nerves.
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
January 1992,
Pharmacological research,
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
November 1990,
British journal of pharmacology,
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
November 1991,
European journal of pharmacology,
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
May 1989,
British journal of pharmacology,
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
October 1992,
British journal of pharmacology,
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
July 2004,
Pancreas,
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
May 1995,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
July 1991,
The Journal of pharmacology and experimental therapeutics,
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
February 1994,
British journal of pharmacology,
L J Jennings, and
G M Salido, and
J A Pariente, and
J S Davison, and
J Singh, and
K A Sharkey
January 2000,
Journal of physiology, Paris,
