Biomaterial Database

No deterioration of glucose tolerance in weight cycling obese. 1996

T Podar, and A Solntsev, and M Väli, and T Vinogradova, and I Podar

Hospital of Endocrinology, Department of Internal Medicine, University of Tartu, Estonia.

OBJECTIVE To evaluate whether weight cycling is detrimental to the changes in glucose tolerance in obese individuals without overt NIDDM and related to the amplitude of weight cycling. METHODS Historical prospective observational study of a hospital-based cohort. METHODS One hundred twenty-five obese individuals drawn from the medical records of the Hospital of Endocrinology, University of Tartu, in whom at least one weight cycle was detected. Selected cutoff value for weight cycling set to 3, 6, 9 and 12 kg of weight loss and subsequent regain. METHODS Weight measurements and oral glucose tolerance tests. The latest oral glucose tolerance test and the one during the first visit compared by the 2 h blood glucose values and areas under the blood glucose curve. RESULTS No deterioration of glucose tolerance recorded in any of the groups with different cutoff values for weight cycling. No trend towards the deterioration of glucose tolerance with increasing amplitude of weight cycles. CONCLUSIONS We cannot claim that weight cycling is detrimental to glucose tolerance in non-diabetic obese individuals. This effect is independent of the amplitude of weight cycling. Weight reduction may be recommended to obese individuals for the prevention of NIDDM even if it is unsuccessful and the phenomenon of weight cycling results.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009765	Obesity	A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D005260	Female		Females
D005951	Glucose Tolerance Test	A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).	Intravenous Glucose Tolerance,Intravenous Glucose Tolerance Test,OGTT,Oral Glucose Tolerance,Oral Glucose Tolerance Test,Glucose Tolerance Tests,Glucose Tolerance, Oral
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D015331	Cohort Studies	Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.	Birth Cohort Studies,Birth Cohort Study,Closed Cohort Studies,Cohort Analysis,Concurrent Studies,Historical Cohort Studies,Incidence Studies,Analysis, Cohort,Cohort Studies, Closed,Cohort Studies, Historical,Studies, Closed Cohort,Studies, Concurrent,Studies, Historical Cohort,Analyses, Cohort,Closed Cohort Study,Cohort Analyses,Cohort Studies, Birth,Cohort Study,Cohort Study, Birth,Cohort Study, Closed,Cohort Study, Historical,Concurrent Study,Historical Cohort Study,Incidence Study,Studies, Birth Cohort,Studies, Cohort,Studies, Incidence,Study, Birth Cohort,Study, Closed Cohort,Study, Cohort,Study, Concurrent,Study, Historical Cohort,Study, Incidence