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The level of 3H-labelled thymidine ([3H]TdR) incorporation of blood cells of patients with coeliac disease was shown in two separate studies to be significantly lower than that of a normal control group. In the first study the 'background' DNA synthesis in unstimulated cultures containing a standard number of blood lymphocytes was measured on days 4, 5 and 6. In the second study a standard volume of freshly drawn whole blood was added to culture medium and the [3H]TdR incorporation measured over the first 24 hr and from 48 to 72 hr. In all cases the [3H]TdR incorporation of cells of coeliac patients on a normal or a gluten-free diet was lower than that of the control group. It is suggested that sequestration of DNA-synthesizing cells in the mucosa of the small bowel may partly explain these results. In whole-blood cultures from patients with inflammatory bowel disease in remission [3H]TdR incorporation over the first 24 hr was raised in Crohn's disease but normal in ulcerative colitis.
G K Holmes, and
P M Bratt, and
N R Ling, and
W T Cooke
July 1980,
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G K Holmes, and
P M Bratt, and
N R Ling, and
W T Cooke
January 2009,
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G K Holmes, and
P M Bratt, and
N R Ling, and
W T Cooke
January 1989,
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G K Holmes, and
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N R Ling, and
W T Cooke
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G K Holmes, and
P M Bratt, and
N R Ling, and
W T Cooke
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G K Holmes, and
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N R Ling, and
W T Cooke
August 2022,
Scientific reports,
G K Holmes, and
P M Bratt, and
N R Ling, and
W T Cooke
January 2016,
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G K Holmes, and
P M Bratt, and
N R Ling, and
W T Cooke
June 1982,
Scandinavian journal of gastroenterology,
G K Holmes, and
P M Bratt, and
N R Ling, and
W T Cooke
January 1998,
The veterinary quarterly,
G K Holmes, and
P M Bratt, and
N R Ling, and
W T Cooke
October 2015,
BMC gastroenterology,
