-transparent.png){kind=logo}
1. The antinociceptive effect of prostaglandins E1, E2 and F2alpha was studied in albino rats. Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E1 (PGE1) produced a dose-related antinociceptive activity. 2. The antinociceptive activities of equi-analgesic doses of morphine (7.5. mg/kg, i.p.) and PGE1 (2.0 mg/kg, i.p.) were inhibited to almost similar extents after pretreatment with drugs known to reduce central turnover of serotonin receptors, namely reserpine, fenclonine (p-chlorophenylalanine), methysergide and 5,6-dihydroxytryptamine. 3. Prostaglandin F2alpha (2.0 mg/kg, i.p.) significantly inhibited the antinociceptive effects of both morphine and PGE1. 4. The prostaglandin synthesis inhibitors, indomethacin and diclofenac, significantly inhibited morphine analgesia. 5. Probenecid markedly prolonged the duration of antinociceptive effect of morphine and the duration of PGE1-induced potentiation of subanalgesic dose of morphine. 6. The results suggest that, in albino rats, PGE1-induced antinociceptive activity is serotonin mediated and that morphine analgesia is not only mediated through serotonin but also through prostaglandins (PGE1 ?) and 5-hydroxyindole acetic acid, the serotonin metabolite.
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
January 1974,
Psychopharmacologia,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
January 1984,
Digestion,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
July 1976,
British journal of pharmacology,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
January 1986,
Psychopharmacology,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
November 1966,
Canadian journal of physiology and pharmacology,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
January 1997,
International journal of colorectal disease,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
May 1981,
British journal of haematology,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
June 1975,
The Journal of organic chemistry,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
November 1973,
Experientia,
A K Sanyal, and
S K Bhattacharya, and
P R Keshary, and
D N Srivastava, and
P K Debnath
October 1976,
Psychopharmacology,
