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In-vivo anti-inflammatory activity of silymarin was tested in different acute inflammation experimental models. In carrageenan-induced paw oedema in rats, silymarin given orally reduced in a dose-dependent manner the food-pad abscesses (ED50 = 62.42 mg kg-1). In xylene-induced ear mouse inflammation, silymarin applied topically was more effective than administered intraperitoneally, with effects comparable with those of indomethacin. Silymarin also produced a dose-dependent inhibition of leukocyte accumulation in inflammatory exudates following intraperitoneal injection of carrageenan in mice; silymarin significantly reduced the number of neutrophils. Silymarin was unable to inhibit phospholipase A2 in an in-vitro assay. Besides its known anti-oxidative properties and its ability to act as a radical scavenger, these results suggest that silymarin exerts an important anti-inflammatory action in-vivo by reducing oedema with the effect markedly influenced by the inhibition of neutrophil migration into the inflamed site.
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
March 1988,
European journal of pharmacology,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
December 1959,
Experientia,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
December 2007,
Journal of leukocyte biology,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
April 1980,
Acta pathologica et microbiologica Scandinavica. Section C, Immunology,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
January 1958,
Farmakologiia i toksikologiia,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
January 1981,
Farmakologiia i toksikologiia,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
November 1978,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
December 1970,
Biulleten' eksperimental'noi biologii i meditsiny,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
September 1959,
Ceskoslovenska fysiologie,
R De La Puerta, and
E Martinez, and
L Bravo, and
M C Ahumada
November 1971,
Nature: New biology,
