-transparent.png){kind=logo}
Effects of multiple drug administration on adverse drug reactions were studied in 10,518 patients hospitalized on a general medical service during a five-year period. Nine index drug groups, including analgesic, antacid, antiarrhythmic, antimicrobic, anticoagulant, antihypertensive, anti-inflammatory, diuretic, and sedative-tranquilizer drugs, were selected for study. The average number of adverse drug reactions for the anticoagulant and antihypertensive drug groups was higher (p less than 0.05) than for all other drug groups when classified by the number of drugs being taken concurrently (i.e., 0 to 5, 6 to 10, etc.). The rate of reaction for anticoagulant and antihypertensive drug groups was higher (p less than 0.001) than the rate for other drug groups studied. These data suggest a higher risk of adverse drug reactions for patients receiving multiple drugs. The increased risk may result from drug interactions.
F E May, and
R B Stewart, and
L E Cluff
January 1986,
Gerontion,
F E May, and
R B Stewart, and
L E Cluff
February 1996,
JAMA,
F E May, and
R B Stewart, and
L E Cluff
March 1977,
Queen's nursing journal,
F E May, and
R B Stewart, and
L E Cluff
October 1977,
The Medical journal of Australia,
F E May, and
R B Stewart, and
L E Cluff
December 2005,
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition,
F E May, and
R B Stewart, and
L E Cluff
March 1974,
Medical arts and sciences,
F E May, and
R B Stewart, and
L E Cluff
January 2022,
Therapeutic advances in chronic disease,
F E May, and
R B Stewart, and
L E Cluff
January 1976,
Heart & lung : the journal of critical care,
F E May, and
R B Stewart, and
L E Cluff
November 2018,
Blood,
F E May, and
R B Stewart, and
L E Cluff
November 2018,
Hematology. American Society of Hematology. Education Program,
