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The susceptibility of severe combined immune deficiency (SCID) mice to experimental systemic cryptococcosis was studied. SCID mice were at least 16-fold more susceptible to lethal infection than were immunocompetent control mice (P < 0.001). Histological assessment showed that control mice responded with a granulomatous inflammatory response, whereas SCID mice showed no evidence of a cellular host response. In a therapeutic study, 5 mg kg-1 day-1 of fluconazole caused a significant reduction in the infectious burden in the spleen, liver, kidney and lungs of treated mice compared with no treatment. These results indicate that a model of systemic cryptococcosis with meningitis in SCID mice may have utility in the study of immunology and therapy of this disease in the severely immunocompromised host.
K V Clemons, and
R Azzi, and
D A Stevens
March 2001,
Antimicrobial agents and chemotherapy,
K V Clemons, and
R Azzi, and
D A Stevens
April 1993,
Laboratory animal science,
K V Clemons, and
R Azzi, and
D A Stevens
August 1992,
Clinical and experimental immunology,
K V Clemons, and
R Azzi, and
D A Stevens
January 2024,
Methods in molecular biology (Clifton, N.J.),
K V Clemons, and
R Azzi, and
D A Stevens
September 1979,
Mycopathologia,
K V Clemons, and
R Azzi, and
D A Stevens
November 1985,
Revista clinica espanola,
K V Clemons, and
R Azzi, and
D A Stevens
November 1952,
American journal of clinical pathology,
K V Clemons, and
R Azzi, and
D A Stevens
January 1980,
Investigative ophthalmology & visual science,
K V Clemons, and
R Azzi, and
D A Stevens
November 1980,
The Indian journal of medical research,
K V Clemons, and
R Azzi, and
D A Stevens
October 1979,
Infection and immunity,
