BIOMAT Database Logo BIOMAT Database Logo

Pharmacological and histopathological aspects of 1-methyl-4-phenyl-4-hydroxy-piperidine (MPIP). 1996

S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
Dipartimento Farmaco Chimico--Facoltà di Farmacia di Bari, Italy.

Increasing dosages of 1-methyl-4-phenyl-4-hydroxypiperidine (MPIP) were administered i.p. to rats. Histopathological examination of these animals revealed effects on the central nervous system.

UI MeSH Term Description Entries
D008297 Male Males
D010880 Piperidines A family of hexahydropyridines.
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002491 Central Nervous System Agents A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252) Central Nervous System Drugs
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
3-Hydroxy-1-methyl-4-(diphenylmethylene)piperidine.
May 1968, Journal of medicinal chemistry,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
A modified method of preparing 1-methyl-4-phenyl-piperidine-4-carboxylic acid derivatives and pharmacological studies of its derivaties.
April 1963, Taehan Naekwa Hakhoe chapchi = The Korean journal of internal medicine,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
[The prepared method of 1-methyl-4-phenyl piperidine-4-carboxylic acid derivatives].
August 1962, Taehan Naekwa Hakhoe chapchi = The Korean journal of internal medicine,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
[Pharmacological studies of a new antitussive, 1-phenethyl-4-hydroxy-salicylamido-4-methyl-piperidine-hydrochloride (S 1592) (author's transl)].
April 1976, Arzneimittel-Forschung,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
Pharmacological and toxicological investigations of 7-hydroxy-4-phenyl-3(4-hydroxy-phenyl)-coumarin (OV1).
July 1987, Indian journal of experimental biology,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
3-Cyclo-propyl-1-(4-methyl-phenyl-sulfon-yl)piperidine-3,5-diol.
January 2012, Acta crystallographica. Section E, Structure reports online,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
Dimethyl cis-4-hydroxy-methyl-piperidine-2,6-dicarboxyl-ate.
April 2010, Acta crystallographica. Section E, Structure reports online,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
Pharmacological actions and acute toxicity of methyl- and phenyl-3-methoxy-4-hydroxy styryl ketones.
June 1987, Arzneimittel-Forschung,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
[Determination of 1-methyl-4-amino-N'-phenyl-N'-(2-thenyl)-piperidine (sandostene-Sandoz)].
July 1957, Die Pharmazie,
S Bruno, and N DeLaurentis, and M A Milillo, and G Tantillo, and A Perillo
Synthesis and smooth muscle-selective relaxant activity of a piperidine analogue: 1-(4'-fluorophenacyl)-4-hydroxy-4-phenyl-piperidinium chloride.
January 2006, Archives of pharmacal research,
Copied contents to your clipboard!