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Molecular cloning and characterization of murine interleukin-11. 1996
J C Morris, and
S Neben, and
F Bennett, and
H Finnerty, and
A Long, and
D R Beier, and
S Kovacic, and
J M McCoy, and
E DiBlasio-Smith, and
E R La Vallie, and
A Caruso, and
J Calvetti, and
G Morris, and
N Weich, and
S R Paul, and
P S Crosier, and
K J Turner, and
C R Wood
Genetics Institute, Inc., Cambridge, MA 02140, USA.
Human interleukin-11 (IL-11) has been shown to have pleiotropic action on hematopoietic, hepatic, stromal, epithelial, neural, and osteoclast cells. In the present work, the murine IL-11 cDNA has been isolated from a fetal thymic cell line, and its structure and function compared with human IL-11. The murine protein was demonstrated to have identical actions on the proliferation of a murine plasmacytoma cell line, murine primitive bone marrow progenitor cells, and megakaryocyte precursors. The murine IL-11 protein was synthesized as a soluble thioredoxin-IL-11 fusion in Escherichia coli and the expression of murine IL-11 was examined by pulse-chase radiolabeling in COS cells. The chromosomal location of the murine IL-11 gene was assigned to the proximal arm of chromosome 7.
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