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OBJECTIVE Aspirin (ASA) and also nonsteroidal anti-inflammatory drug (NSAID) use has been associated with a low incidence of colorectal cancer. The incidence of colorectal cancer in a cohort of patients with rheumatoid arthritis (RA) is reported here. METHODS Cancer incidence was studied in a cohort of 9469 persons hospitalized for RA during 1970-1991 in Finland. The follow-up time was about 65,400 person-years. RESULTS The incidence of colon cancer was significantly lower than in the general population [standardized incidence ratio (SIR) 0.57; 95% confidence interval (CI) 0.33-0.93], and the combined SIR for colorectal cancer was 0.62 (95% CI 0.42-0.88), while the combined incidence of all malignancies (SIR 1.16; 95% CI 1.07-1.26) was higher in RA patients than in the general population. CONCLUSIONS Chronic use of NSAIDs or ASA, including antiinflammatory doses, is probably the main explanation for the low incidence of colorectal cancer in RA patients.
M Kauppi, and
E Pukkala, and
H Isomäki
February 1993,
Journal of the National Cancer Institute,
M Kauppi, and
E Pukkala, and
H Isomäki
January 1970,
British medical journal,
M Kauppi, and
E Pukkala, and
H Isomäki
October 1996,
Ryumachi. [Rheumatism],
M Kauppi, and
E Pukkala, and
H Isomäki
January 1987,
Clinical and experimental rheumatology,
M Kauppi, and
E Pukkala, and
H Isomäki
January 1994,
Scandinavian journal of rheumatology,
M Kauppi, and
E Pukkala, and
H Isomäki
January 2000,
Przeglad lekarski,
M Kauppi, and
E Pukkala, and
H Isomäki
January 1974,
Arthritis and rheumatism,
M Kauppi, and
E Pukkala, and
H Isomäki
November 2011,
Rheumatology international,
M Kauppi, and
E Pukkala, and
H Isomäki
April 1991,
The Journal of rheumatology,
M Kauppi, and
E Pukkala, and
H Isomäki
January 2021,
Reumatologia clinica,
