Biomaterial Database

First isolation and characterization of very virulent Marek's disease virus in Taiwan. 1996

J A Lin, and C P Chen

Department of Veterinary Medicine, National Chung Hsing University, Taiwan, Republic of China.

Isolation of very virulent Marek's disease virus (vvMDV) was carried out by inoculating blood and spleen samples of Marek's disease (MD) chickens onto chicken embryo fibroblast cell cultures and into the peritoneal cavity of one-day-old chicks. Seven isolates of MDV were isolated in this experiment. By the results of cytopathic effect and fluorescent antibody tests, the 7 isolates were divided into 3 serotypes: serotype 1 of strains LTB-1, -2, -3, LTS-1, and -2; serotype 2 of strain LTB-4; and serotype 3 of strain LTB-5. Strain LTB-1 was used to inoculate experimental chickens of both layers and broilers. Early phase mortality and markedly atrophied lymphoid organs were observed during 0-2nd week post-inoculation (PI) and at 5th week PI, respectively, but were not found in uninoculated chickens. In addition, experimental chickens vaccinated with (HVT) vaccine at 1 day old and challenged with strain LTB-1 at 10th day post-vaccination, revealed early phase death before 2nd week post-challenged (PC), and lymphomatous lesions before 10th week PC. From these results of this in vivo experiment, strain LTB-1 showed the same pathogenicity as that of vvMDV, and this is the first report of vvMDV being isolated and identified in Taiwan.

UI	MeSH Term	Description	Entries
D008380	Marek Disease	A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.	Fowl Paralysis,Marek's Disease,Fowl Paralyses,Mareks Disease,Paralyses, Fowl,Paralysis, Fowl
D008381	Herpesvirus 2, Gallid	The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds.	Fowl Paralysis Virus,Marek's Disease Herpesvirus 1,Marek's Disease Virus Serotype 1,Neurolymphomatosis Virus,Gallid Herpesvirus 2,Herpesvirus 2 (gamma), Gallid,Marek Disease Herpesvirus 1,Fowl Paralysis Viruses,Neurolymphomatosis Viruses,Paralysis Virus, Fowl,Paralysis Viruses, Fowl
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013624	Taiwan	Country in eastern Asia, islands bordering the East China Sea, Philippine Sea, South China Sea, and Taiwan Strait, north of the Philippines, off the southeastern coast of China. The capital is Taipei. The alternate country name is Republic of China.	Formosa,Republic of China
D014765	Viral Vaccines	Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.	Viral Vaccine,Vaccine, Viral,Vaccines, Viral