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The antagonistic effects of atipamezole (20, 40, 60, 80, and 100 micrograms/kg i.v.) on medetomidine (10 micrograms/kg i.v.)-induced sedation were evaluated in horses. Although 20 and 40 micrograms/kg of atipamezole were not sufficient to reverse the sedation, 60 micrograms/kg did effectively reverse the sedation. Atipamezole at 80 micrograms/kg was more potent, and significantly shortened the duration of sedation without any apparent side effects, but a higher dose of 100 micrograms/kg was not more effective than 80 micrograms/kg. The possible use of atipamezole as a reversal agent may enhance the value and availability of medetomidine as a chemical restraint agent in horses.
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
October 1993,
The Journal of veterinary medical science,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
October 2009,
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
March 2014,
The Journal of veterinary medical science,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
October 1994,
The Journal of veterinary medical science,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
December 1992,
The Journal of veterinary medical science,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
March 1990,
Journal of veterinary pharmacology and therapeutics,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
January 2003,
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
April 1995,
Veterinary and human toxicology,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
October 1997,
Journal of veterinary pharmacology and therapeutics,
K Yamashita, and
K Yonezawa, and
Y Izumisawa, and
T Kotani
August 1991,
American journal of veterinary research,
