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We examined the effect of two different types of tyrosine kinase inhibitor, herbimycin A and genistein, on antigen-induced tracheal contraction and antigen-induced histamine release from the trachea in sensitized guinea pigs in vitro. Herbimycin A (1-10 microM) and genistein (1-10 microM) significantly inhibited antigen-induced tracheal contraction, compared with control. Additionally, herbimycin A (1-10 microM) and genistein (3-10 microM) significantly inhibited antigen-induced histamine release from the trachea in a concentration-dependent manner, compared with control. On the contrary, herbimycin A and genistein did not suppress acetylcholine- and histamine-induced tracheal contraction. We concluded that herbimycin A and genistein inhibit antigen-induced tracheal contraction without inhibiting smooth muscle contractility, and these inhibitory effects are due to, at least partially, inhibiting histamine release from tracheal mast cells.
H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
October 1996,
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
February 1996,
Canadian journal of anaesthesia = Journal canadien d'anesthesie,
H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
March 1996,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
January 1985,
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H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
December 1982,
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H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
September 1992,
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H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
May 1983,
Arerugi = [Allergy],
H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
September 2002,
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H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
May 1998,
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H Iwagoe, and
H Kohrogi, and
K Fujii, and
J Hamamoto, and
N Hirata, and
M Ando
January 1993,
International archives of allergy and immunology,
