Biomaterial Database

Expression of proliferating cell nuclear antigen in node-negative human prostate cancer. 1996

H A Idikio

Department of Laboratory Medicine and Pathology, University of Alberta, Canada. hidikio@gpu.srv.ualberta.ca

Cancer cell proliferation could be an important predictor of clinical behavior and survival in node-negative prostate cancers. Proliferating cell nuclear antigen (PCNA; PC10) immunostaining was determined in 38 prostate biopsies and transurethral resections in clinically organ confined prostate cancers. 14 of the prostate cancers were Gleason score 2-4 and 24 were Gleason score 5-7. 29 were stage T2 and 9 were stage T3. Gleason score 2-4 cancers had a mean PCNA of 7.08 (s.d 5.1); Gleason score 5-7 had a mean PCNA of 11.42 (s.d 7.7), Stage T2 cancers had a mean PCNA of 8.007 (s.d 6.13) and stage T3 cancers had a mean PCNA of 12.7 (s.d 8.49). 21.4% of Gleason score 2-4, 12.5% of Gleason score 5-7, 10.7% of stage T2 and 10% of stage T3 had mean PCNA counts of twice their mean values. 4/24 (16.67%) of Gleason score 5-7 and 28.57% of stage T3 cancers had total PCNA counts > 20/2hpf suggesting high counts are indices of progression.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009367	Neoplasm Staging	Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.	Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011471	Prostatic Neoplasms	Tumors or cancer of the PROSTATE.	Cancer of Prostate,Prostate Cancer,Cancer of the Prostate,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Neoplasms,Prostatic Cancer,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Prostate Cancers,Prostate Neoplasm,Prostatic Cancers,Prostatic Neoplasm
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000951	Antigens, Neoplasm	Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.	Neoplasm Antigens,Tumor Antigen,Tumor Antigens,Antigen, Tumor,Antigens, Tumor
D018809	Proliferating Cell Nuclear Antigen	Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.	Antigen, Proliferating Cell Nuclear,PCNA