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Tinidazole was found to display much higher mutagenic activity compared to metronidazole in Salmonella strain TA100 and YG1029. Under anaerobiosis, the specific activity of this nitroimidazole was enhanced, at least, by about 1.75-fold in TA100 and several fold in TA100NR relative to aerobic conditions. The mutagenicity in the latter strain with S9 mix became further increased by 2.5-fold under anaerobiosis, indicating the role of oxygen sensitive bacterial and mammalian S9 nitroreductases in the activation of the drug. The mutagenicity of the drug was slightly lowered in TA100/1,8-DNP6 (O-acetyltransferase deficient), YG1029 (O-acetyltransferase overexpressing) and TA100 in the presence of pentachlorophenol (PCP), an O-acetyltransferase inhibitor. These results rule out the possible involvement of N-acetoxyarylamine pathway in the metabolic activation of these nitroimidazoles.
R L Gupta, and
V Vats, and
T R Juneja
December 2005,
Clinical therapeutics,
R L Gupta, and
V Vats, and
T R Juneja
February 1981,
Journal of applied toxicology : JAT,
R L Gupta, and
V Vats, and
T R Juneja
January 1969,
Antimicrobial agents and chemotherapy,
R L Gupta, and
V Vats, and
T R Juneja
July 1976,
Biochemical pharmacology,
R L Gupta, and
V Vats, and
T R Juneja
August 2001,
Toxicological sciences : an official journal of the Society of Toxicology,
R L Gupta, and
V Vats, and
T R Juneja
February 1980,
Biochemical pharmacology,
R L Gupta, and
V Vats, and
T R Juneja
December 1987,
Carcinogenesis,
R L Gupta, and
V Vats, and
T R Juneja
January 1998,
Environmental and molecular mutagenesis,
R L Gupta, and
V Vats, and
T R Juneja
April 1980,
Mutation research,
R L Gupta, and
V Vats, and
T R Juneja
January 1992,
Xenobiotica; the fate of foreign compounds in biological systems,
