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The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa were investigated in vitro. Normal mucosa was surgically obtained from human paranasal sinuses and incubated in the form of tissue culture. Ciliated cells were magnified under an inverted microscope, and ciliary activity was photoelectrically measured. LTD4 progressively inhibited ciliary activity, and showed a more potent effect on ciliary activity compared to LTC4. The concentrations of LTC4 and LTD4 in the incubation medium were determined by radioimmunoassay when the mucosa was incubated with 10(-8) M LTC4. The concentration of LTD4 gradually increased and after 90 min reached the maximum of 0.71 x 10(-8) M, while that of LTC4 was reduced to about 10% of its initial concentration within 60 min. These results suggested the possible conversion of LTC4 to LTD4 on the mucosa, and that LTC4 can inhibit ciliary activity by means of LTD4.
T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
April 1998,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
February 1983,
Prostaglandins,
T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
April 1982,
The Journal of pharmacology and experimental therapeutics,
T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
November 1992,
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T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
October 1987,
Prostaglandins, leukotrienes, and medicine,
T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
November 1992,
Nihon Jibiinkoka Gakkai kaiho,
T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
January 1985,
Lung,
T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
May 1987,
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T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
July 1988,
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T Ganbo, and
K Hisamatsu, and
H Inoue, and
A Mizukoshi, and
R Goto, and
Y Murakami
April 1983,
The American journal of physiology,
