Biomaterial Database

[Parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in the gastrointestinal tract]. 1996

M Ito, and A Ohtsuru

Department of Pathology, Nagasaki University, School of Medicine.

Parathyroid hormone-related peptide (PTHrP), originally isolated as a responsible factor for humoral hypercalcemia of malignancy, has been demonstrated to overexpress even in non-hypercalcemic gastrointestinal malignancies. PTHrP and its receptor mRNA expression has been detected in a variety of normal tissues in neonate and adults. PTHrP might be involved in growth and differentiation on fetal gut epithelium, and an important gastrointestinal peptide which regulates gastrointestinal contractile activity in a paracrine/autocrine fashion. Exogenous PTHrP shows a relaxant effect on gastrointestinal muscle strips through PTH/PTHrP receptor in vitro. Increase PTHrP mRNA was induced by distention and contraction in the smooth muscle of the stomach, and stress-induced abnormal contractions was deeply related to PTHrP suppression by steroid.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009130	Muscle, Smooth	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)	Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D011506	Proteins	Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.	Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D004064	Digestive System	A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).	Ailmentary System,Alimentary System
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D044162	Parathyroid Hormone-Related Protein	A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.	Hypercalcemic Hormone of Malignancy,PTH Like Tumor Factor,PTH-Like Protein,PTH-Related Peptide,PTHrP,Parathyroid Hormone Like Tumor Factor,Parathyroid Hormone-Like Protein,Parathyroid Hormone-Related Peptide,Tumor Hypercalcemic Factor,Hormone-Related Protein, Parathyroid,Hypercalcemic Factor, Tumor,PTH Like Protein,PTH Related Peptide,Parathyroid Hormone Like Protein,Parathyroid Hormone Related Peptide,Parathyroid Hormone Related Protein
D044168	Receptor, Parathyroid Hormone, Type 1	A parathyroid hormone receptor subtype that recognizes both PARATHYROID HORMONE and PARATHYROID HORMONE-RELATED PROTEIN. It is a G-protein-coupled receptor that is expressed at high levels in BONE and in KIDNEY.	Parathyroid Hormone Receptor Type 1,PTH-PTHrP Receptor,PTH-Related Peptide Receptor,PTH-Related Protein Receptor,PTHLP Receptor,PTHrP Receptor,Parathyroid Hormone Receptor,Parathyroid Hormone Receptor 1,Parathyroid Hormone Receptor Type I,Parathyroid Hormone-Like Peptide Receptor,Parathyroid Hormone-Related Peptide Receptor,Receptor, Parathyroid Hormone-Like Peptide,PTH PTHrP Receptor,PTH Related Peptide Receptor,PTH Related Protein Receptor,Parathyroid Hormone Like Peptide Receptor,Parathyroid Hormone Related Peptide Receptor,Receptor, PTH-PTHrP,Receptor, PTH-Related Peptide,Receptor, PTH-Related Protein,Receptor, PTHLP,Receptor, PTHrP,Receptor, Parathyroid Hormone
D018016	Receptors, Parathyroid Hormone	Cell surface proteins that bind PARATHYROID HORMONE with high affinity and trigger intracellular changes which influence the behavior of cells. Parathyroid hormone receptors on BONE; KIDNEY; and gastrointestinal cells mediate the hormone's role in calcium and phosphate homeostasis.	Parathyroid Hormone Receptors