-transparent.png){kind=logo}
Magnetopneumography was applied to investigate intracellular phagosome motion in alveolar macrophage cells of healthy subjects (non-smokers and smokers). Ingested magnetic microparticles are inhaled and phagocytized by alveolar macrophages within hours. Thereby the particles are transferred into phagolysosomes. After magnetization the particles produce a macroscopic magnetic field of the lungs. Cellular motility causes a decay of the field (relaxation) by stochastic disorientation of the dipole particles (phagolysosomes) in the cells. Our studies have shown that the deposition of magnetite test particles induces a non-specific activation of the macrophage cells with a faster relaxation. This activation vanishes within the first day after particle deposition. This macrophage activation due to dust exposure was not present in smokers. It follows that cigarette smoking either causes a damage of the cellular defense or causes an adaptation of the macrophage cells to the permanent cigarette smoke inhalation.
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
August 2008,
The Journal of allergy and clinical immunology,
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
January 2005,
Pediatric research,
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
January 1996,
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology,
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
December 2005,
American journal of respiratory and critical care medicine,
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
January 1995,
Methods in molecular biology (Clifton, N.J.),
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
May 2016,
Toxicological sciences : an official journal of the Society of Toxicology,
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
August 1981,
Immunology today,
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
January 2014,
Veterinary immunology and immunopathology,
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
December 1978,
Toxicology,
W Möller, and
W Barth, and
W Pohlit, and
M Rust, and
R Siekmeier, and
W Stahlhofen, and
J Heyder
December 1999,
Anesthesiology,
