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By comparing lists of 3'-directed partial cDNA sequences (gene signatures) randomly collected from various tissues, genes uniquely expressed in individual tissue can be identified. A full length cDNA clone, corresponding to one such gene signature, unique to human osteoblast and adipose tissue, was isolated. This cDNA clone encodes a 845-amino acid protein that is almost identical to the mouse adipocyte transcription factor AEBP1 except that it has additional 105 amino acids in the N terminus. A northern hybridization showed that in the differentiating murine osteoblastic cell line, AEBP1 is also expressed but that it is shut off in the final calcification phase, suggesting a transcriptional repressive effect on genes for bone formation.
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January 2001,
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao,
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July 2003,
Sheng wu gong cheng xue bao = Chinese journal of biotechnology,
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August 1995,
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June 1993,
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December 2008,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
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September 1994,
Journal of biochemistry,
I Ohno, and
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K Okubo
November 2016,
Oncotarget,
I Ohno, and
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K Takaoka, and
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K Okubo
January 1987,
Blood,
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March 2009,
Cancer investigation,
