BIOMAT Database Logo BIOMAT Database Logo

Long-term depression at the medial perforant path-granule cell synapse in developing rat dentate gyrus. 1996

B L Trommer, and Y B Liu, and J F Pasternak
Division of Pediatric Neurology, Evanston Hospital, IL 60201, USA. btrommer@nwu.edu

Long-term depression (LTD) is a decrease in synaptic efficacy that may model the elimination of inappropriate synapses during brain development. LTD might therefore be expected to be prominent in the juvenile hippocampal dentate gyrus (DG), where the majority of neuronogenesis and excitatory synapse production and pruning occur in the first postnatal month. Thus far, however, LTD in immature DG remains unexplored. Low-frequency stimulus induced homosynaptic LTD was studied at the medial perforant path-granule cell synapse in rats 8-30 days of age. LTD was most consistent and was of greatest magnitude in the youngest animals, and was more robust in response to stimulation at 1 Hz than at 3 or 5 Hz. LTD was saturable by repetitive delivery of low-frequency stimulation, and reversible by tetanic stimulation that induced long-term potentiation (LTP). LTD of the field EPSP was not prevented by bath application of the NMDA receptor antagonist AP5, the mGluR antagonist MCPG, or the L-type voltage sensitive calcium channel antagonist nitrendipine. In whole cell recordings LTD induction was blocked by hyperpolarization of the postsynaptic neuron but not by calcium chelation with BAPTA. Calcium chelation blocked LTP and simultaneously unmasked tetanus induced LTD. These data demonstrate that LTD is prominent in immature DG, that LTP and LTD are complementary processes, and that LTD is likely to be induced postsynaptically because it is voltage dependent, although the mechanism of voltage dependence remains to be elucidated.

UI MeSH Term Description Entries
D008297 Male Males
D009473 Neuronal Plasticity The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations. Brain Plasticity,Plasticity, Neuronal,Axon Pruning,Axonal Pruning,Dendrite Arborization,Dendrite Pruning,Dendritic Arborization,Dendritic Pruning,Dendritic Remodeling,Neural Plasticity,Neurite Pruning,Neuronal Arborization,Neuronal Network Remodeling,Neuronal Pruning,Neuronal Remodeling,Neuroplasticity,Synaptic Plasticity,Synaptic Pruning,Arborization, Dendrite,Arborization, Dendritic,Arborization, Neuronal,Arborizations, Dendrite,Arborizations, Dendritic,Arborizations, Neuronal,Axon Prunings,Axonal Prunings,Brain Plasticities,Dendrite Arborizations,Dendrite Prunings,Dendritic Arborizations,Dendritic Prunings,Dendritic Remodelings,Network Remodeling, Neuronal,Network Remodelings, Neuronal,Neural Plasticities,Neurite Prunings,Neuronal Arborizations,Neuronal Network Remodelings,Neuronal Plasticities,Neuronal Prunings,Neuronal Remodelings,Neuroplasticities,Plasticities, Brain,Plasticities, Neural,Plasticities, Neuronal,Plasticities, Synaptic,Plasticity, Brain,Plasticity, Neural,Plasticity, Synaptic,Pruning, Axon,Pruning, Axonal,Pruning, Dendrite,Pruning, Dendritic,Pruning, Neurite,Pruning, Neuronal,Pruning, Synaptic,Prunings, Axon,Prunings, Axonal,Prunings, Dendrite,Prunings, Dendritic,Prunings, Neurite,Prunings, Neuronal,Prunings, Synaptic,Remodeling, Dendritic,Remodeling, Neuronal,Remodeling, Neuronal Network,Remodelings, Dendritic,Remodelings, Neuronal,Remodelings, Neuronal Network,Synaptic Plasticities,Synaptic Prunings
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002121 Calcium Channel Blockers A class of drugs that act by selective inhibition of calcium influx through cellular membranes. Calcium Antagonists, Exogenous,Calcium Blockaders, Exogenous,Calcium Channel Antagonist,Calcium Channel Blocker,Calcium Channel Blocking Drug,Calcium Inhibitors, Exogenous,Channel Blockers, Calcium,Exogenous Calcium Blockader,Exogenous Calcium Inhibitor,Calcium Channel Antagonists,Calcium Channel Blocking Drugs,Exogenous Calcium Antagonists,Exogenous Calcium Blockaders,Exogenous Calcium Inhibitors,Antagonist, Calcium Channel,Antagonists, Calcium Channel,Antagonists, Exogenous Calcium,Blockader, Exogenous Calcium,Blocker, Calcium Channel,Blockers, Calcium Channel,Calcium Blockader, Exogenous,Calcium Inhibitor, Exogenous,Channel Antagonist, Calcium,Channel Blocker, Calcium,Inhibitor, Exogenous Calcium
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D005071 Evoked Potentials Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported. Event Related Potential,Event-Related Potentials,Evoked Potential,N100 Evoked Potential,P50 Evoked Potential,N1 Wave,N100 Evoked Potentials,N2 Wave,N200 Evoked Potentials,N3 Wave,N300 Evoked Potentials,N4 Wave,N400 Evoked Potentials,P2 Wave,P200 Evoked Potentials,P50 Evoked Potentials,P50 Wave,P600 Evoked Potentials,Potentials, Event-Related,Event Related Potentials,Event-Related Potential,Evoked Potential, N100,Evoked Potential, N200,Evoked Potential, N300,Evoked Potential, N400,Evoked Potential, P200,Evoked Potential, P50,Evoked Potential, P600,Evoked Potentials, N100,Evoked Potentials, N200,Evoked Potentials, N300,Evoked Potentials, N400,Evoked Potentials, P200,Evoked Potentials, P50,Evoked Potentials, P600,N1 Waves,N2 Waves,N200 Evoked Potential,N3 Waves,N300 Evoked Potential,N4 Waves,N400 Evoked Potential,P2 Waves,P200 Evoked Potential,P50 Waves,P600 Evoked Potential,Potential, Event Related,Potential, Event-Related,Potential, Evoked,Potentials, Event Related,Potentials, Evoked,Potentials, N400 Evoked,Related Potential, Event,Related Potentials, Event,Wave, N1,Wave, N2,Wave, N3,Wave, N4,Wave, P2,Wave, P50,Waves, N1,Waves, N2,Waves, N3,Waves, N4,Waves, P2,Waves, P50
D005260 Female Females
D005998 Glycine A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. Aminoacetic Acid,Glycine, Monopotassium Salt,Glycine Carbonate (1:1), Monosodium Salt,Glycine Carbonate (2:1), Monolithium Salt,Glycine Carbonate (2:1), Monopotassium Salt,Glycine Carbonate (2:1), Monosodium Salt,Glycine Hydrochloride,Glycine Hydrochloride (2:1),Glycine Phosphate,Glycine Phosphate (1:1),Glycine Sulfate (3:1),Glycine, Calcium Salt,Glycine, Calcium Salt (2:1),Glycine, Cobalt Salt,Glycine, Copper Salt,Glycine, Monoammonium Salt,Glycine, Monosodium Salt,Glycine, Sodium Hydrogen Carbonate,Acid, Aminoacetic,Calcium Salt Glycine,Cobalt Salt Glycine,Copper Salt Glycine,Hydrochloride, Glycine,Monoammonium Salt Glycine,Monopotassium Salt Glycine,Monosodium Salt Glycine,Phosphate, Glycine,Salt Glycine, Monoammonium,Salt Glycine, Monopotassium,Salt Glycine, Monosodium
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001565 Benzoates Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure. Benzoate,Benzoic Acids,Acids, Benzoic

Related Publications

B L Trommer, and Y B Liu, and J F Pasternak
Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus.
July 2019, Neuropharmacology,
B L Trommer, and Y B Liu, and J F Pasternak
Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse.
January 1991, The Journal of pharmacology and experimental therapeutics,
B L Trommer, and Y B Liu, and J F Pasternak
Synaptic fatigue at the naive perforant path-dentate granule cell synapse in the rat.
December 2005, The Journal of physiology,
B L Trommer, and Y B Liu, and J F Pasternak
ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses.
January 2012, Neural plasticity,
B L Trommer, and Y B Liu, and J F Pasternak
Unscheduled brain DNA synthesis, long-term potentiation, and depression at the perforant path-granule cell synapse in the rat.
January 1995, Brain research bulletin,
B L Trommer, and Y B Liu, and J F Pasternak
Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus.
March 1975, Brain research,
B L Trommer, and Y B Liu, and J F Pasternak
Application of N-methyl-D-aspartate induces long-term potentiation in the medial perforant path and long-term depression in the lateral perforant path of the rat dentate gyrus in vitro.
February 2001, Neuroscience letters,
B L Trommer, and Y B Liu, and J F Pasternak
Potentiation of monosynaptic EPSPs in the perforant path-dentate granule cell synapse.
January 1971, Experimental brain research,
B L Trommer, and Y B Liu, and J F Pasternak
Brain RNA synthesis, long-term potentiation and depression at the perforant path-granule cell synapse in the guinea pig.
January 1995, Brain research bulletin,
B L Trommer, and Y B Liu, and J F Pasternak
Analysis of short-term plasticity at the perforant path-granule cell synapse.
December 1979, Brain research,
Copied contents to your clipboard!