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The present study was designed to produce the experimental carcinoma of the biliary tract in dogs. Tube cholecystostomy was constructed in 8 mongrel dogs and 5-10 ml of 0.7-1.0 mg/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) was administered through the tube every day for the maximum period of 180 days. As the results: The experiment had to be cut off in 7 dogs (5 dogs: The tube was inadvertently pulled out. 2 dogs: died of general weakness). Pathological changes were observed in one dog given ENNG for 180 days and sacrificed at 372 days after the beginning of the experiment. Macroscopically, scattered foci of flat elevation of the mucosa were observed in the entire mucosal surface of common bile duct and a tiny polypoid lesion at the terminal protion. A tiny polypoid projection was adenocarcinoma confined to the mucosa, and areas of flat elevation showed marked hyperplasia of mucosa with partial atypical proliferation. No remarkable findings were noted in other organs.
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
November 1978,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
January 1984,
Nihon Geka Gakkai zasshi,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
April 1984,
Igaku kenkyu. Acta medica,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
March 1982,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
January 1980,
Journal of cancer research and clinical oncology,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
June 1977,
Journal of the National Cancer Institute,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
August 1983,
International journal of cancer,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
December 1983,
Nihon Ika Daigaku zasshi,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
December 1977,
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology,
S Nakazawa, and
Y Naito, and
Y Yamamoto, and
H Yamase, and
K Sobue, and
K Yamada, and
T Yamamoto, and
M Ichikawa, and
H Hidano, and
T Kachi, and
S Hayashi, and
M Kazikawa, and
T Hattori
December 1982,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
