The vascular organization of sympathetic ganglia has been reviewed in relation to type II small intensely-fluorescent (SIF) cells. These cells are considered to be secretory cells forming large clusters surrounded by fenestrated capillaries. Immunohistochemical studies have revealed the existence of many kinds of peptides, in addition to catecholamines, in type II SIF cells. These transmitters are thought to enter the bloodstream, perfuse the adjacent ganglionic tissue, and modify the synaptic transmission and activity of sympathetic ganglionic neurons. Several authors reported portal-like intraganglionic microcirculation through which type II SIF cells participate in modulation of the principal ganglionic neurons. One large intraganglionic portal sinus located between SIF cells and principal ganglionic neurons was also reported in the inferior mesenteric ganglion. However, some authors claimed that transmitters could be absorbed through numerous capillary anastomoses, without any portal system in the superior cervical ganglion. It is noticed that the number, size, and partition of SIF-cell clusters are variable in different ganglia and different animal species. It is important to interpret the functional and morphological correlates of intraganglionic microcirculation based on the species and location of ganglia.