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Recent identification of gene mutations responsible for hereditary nonpolyposis colorectal cancer (HNPCC) has made possible the presymptomatic diagnosis of at-risk family members. If DNA testing shows that a family member is a gene carrier, that individual's lifetime cancer risk is approximately 90%. If the test is negative, the family member's cancer risk drops to that of the general population. Presymptomatic DNA-based diagnosis consists of pretest counseling, the actual DNA test, and posttest counseling. Pretest counseling focuses on the benefits, limitations, and possible adverse effects of testing, and the advantages and drawbacks of screening methods. Posttest counseling sessions explore the test result, and family members' reactions to it. A multidisciplinary team approach is necessary for the management of HNPCC families.
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
January 1996,
Cancer,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
March 2003,
Archives of internal medicine,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
December 1996,
The American journal of gastroenterology,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
January 2004,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
May 2003,
The American surgeon,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
January 2003,
Current opinion in gastroenterology,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
February 2001,
Diseases of the colon and rectum,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
January 2004,
World journal of gastroenterology,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
July 2017,
Current protocols in human genetics,
F H Menko, and
J T Wijnen, and
P M Khan, and
H F Vasen, and
M H Oosterwijk
April 2009,
Current protocols in human genetics,
