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Intracytoplasmic sperm injection (ICSI), treatment of severe male infertility allows an accurate evaluation of oocyte maturity at recovery after corona-cell removal. In cycles comprising a GnRH analog desensitization and a stimulation by hMG or FSH, 12% of oocytes aspirated from follicles (> 14 mm), 34 hours post-hCG are still immature, in prophase or metaphase 1. They are able to achieve meiosis in vitro in 66% of the cases and will be fertilized (2 PN) by ICSI in 51% of the cases as the in vivo mature oocytes of the same cohort. Nevertheless, the quality of cytoplasmic maturation and consequently of embryonic viability remains to be assessed as there still are few pregnancies arising from in vitro matured oocytes. ICSI also represents the only way to obtain normal fertilization in some exceptional but observed anomalies of oocyte maturation, particularly when there is a lack of zona reaction leading to repetitive polyspermy in conventional IVF.
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
March 2020,
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
July 2010,
Fertility and sterility,
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
June 1994,
Human reproduction (Oxford, England),
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
March 1994,
Human reproduction (Oxford, England),
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
November 1995,
Human reproduction (Oxford, England),
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
January 2010,
Case reports in medicine,
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
June 1997,
Human reproduction (Oxford, England),
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
January 1998,
Reproduction, fertility, and development,
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
November 1995,
Human reproduction (Oxford, England),
J Mandelbaum, and
A M Junca, and
J Belaisch-Allart, and
J Salat-Baroux, and
M Plachot, and
J M Antoine, and
P Merviel, and
J M Mayenga, and
J Cohen
January 2012,
Obstetrics and gynecology international,
