-transparent.png){kind=logo}
Five novel 1,2-sn-diacylglycerols with diterpenoid acyl moieties in the sn-1 position were isolated and characterized, together with the corresponding 1,3-sn-diacylglycerols, from three species of dorid nudibranchs molluscs. Their potent activity as morphogens in vivo in the Hydra tentacle regeneration assay and their parallel activity as activators of rat brain protein kinase C (PKC) in vitro are reported here. Our findings promote the use of these compounds as useful molecular probes for both in vivo and in vitro studies on the participation of PKC in cell development.
Related Publications
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
January 2004,
Molecular membrane biology,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
June 2003,
Accounts of chemical research,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
January 1986,
Methods in enzymology,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
March 1991,
Experimental cell research,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
January 2006,
Progress in molecular and subcellular biology,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
March 2006,
Journal of medicinal chemistry,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
December 1995,
Biochemical and biophysical research communications,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
January 1990,
Life sciences,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
September 2016,
Nature chemical biology,
L De Petrocellis, and
P Orlando, and
M Gavagnin, and
M Ventriglia, and
G Cimino, and
V Di Marzo
October 1984,
Biochemistry,
