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To explore the effect of physiological elevations of glucagon on plasma triglyceride concentration, glucagon was infused for thirty minutes at 3.0 ng/kg/min into both normal and insulin dependent diabetic subjects. The effects of this hormonal infusion on plasma triglyceride, free fatty acids, glucose, and insulin were compared to a control saline infusion study. A differential effect of glucagon on plasma triglyceride concentration between normal and diabetic subjects was observed. In normal subjects, glucagon infusion was accompanied by a concomitant increase in endogenous insulin secretion and free fatty acid levels, and no observable effect on circulating plasma triglyceride concentration. In contrast, in diabetic subjects, no change in insulin or free fatty acid concentration occurred during glucagon infusion and circulating plasma triglyceride concentration declined after twenty minutes of hormone infusion. These results suggest that plasma triglyceride concentration may be modulated, at least in part, by alterations in circulating plasma glucagon in concert with insulin secretion and free fatty acid availability in man.
D S Schade, and
R P Eaton
August 1977,
Diabetologia,
D S Schade, and
R P Eaton
May 1988,
Journal of reproduction and fertility,
D S Schade, and
R P Eaton
October 1980,
The Journal of clinical endocrinology and metabolism,
D S Schade, and
R P Eaton
January 1972,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
D S Schade, and
R P Eaton
July 1963,
Metabolism: clinical and experimental,
D S Schade, and
R P Eaton
January 1972,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
D S Schade, and
R P Eaton
May 1976,
The Journal of clinical endocrinology and metabolism,
D S Schade, and
R P Eaton
November 1969,
Diabetes,
D S Schade, and
R P Eaton
October 1980,
Metabolism: clinical and experimental,
D S Schade, and
R P Eaton
April 1972,
Metabolism: clinical and experimental,
