Biomaterial Database

Contribution of the dorsal nucleus of the lateral lemniscus to binaural responses in the inferior colliculus of the rat: interaural time delays. 1996

S A Kidd, and J B Kelly

Laboratory of Sensory Neuroscience, Carleton University, Ottawa, Ontario, Canada.

The contribution of the dorsal nucleus of the lateral lemniscus (DNLL) to binaural responses in the inferior colliculus of the rat was determined for a wide range of interaural time differences (ITDs). Single-unit action potentials were recorded from the inferior colliculus before and after local injection of the excitatory amino acid antagonist kynurenic acid into the DNLL. Binaural properties were determined by manipulating the time difference between paired clicks delivered to the ears ipsilateral and contralateral to the recording site. The probability of an action potential decreased as contralateral stimulation was delayed, relative to ipsilateral stimulation. These data generated a sigmoidal ITD curve for delays between -1.0 and + 1.0 msec. By extending the time intervals beyond 1 msec, it was possible to determine the trailing edge of the inhibition produced by ipsilateral stimulation. The duration of the inhibitory effect varied from cell to cell but lasted as long as 20 msec in some cases. Injection of kynurenic acid into the DNLL contralateral to the recording site reduced the extent of both short (0-1 msec) and long-lasting (1-20 msec) inhibition in the inferior colliculus. No effect was seen after injections ipsilateral to the recording site. The data demonstrate that the DNLL plays an important role in shaping ITD responses in the inferior colliculus and contributes to both the short and long-lasting inhibition produced by stimulation of the ipsilateral ear.

UI	MeSH Term	Description	Entries
D007245	Inferior Colliculi	The posterior pair of the quadrigeminal bodies which contain centers for auditory function.	Colliculus, Inferior,Brachial Nucleus of the Inferior Colliculus,Caudal Colliculus,Colliculus Inferior,Inferior Colliculus,Posterior Colliculus,Colliculi, Inferior,Colliculus Inferiors,Colliculus, Caudal,Colliculus, Posterior,Inferior, Colliculus,Inferiors, Colliculus
D007736	Kynurenic Acid	A broad-spectrum excitatory amino acid antagonist used as a research tool.	Kynurenate,Acid, Kynurenic
D008297	Male		Males
D008845	Microinjections	The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.	Microinjection
D009475	Neurons, Afferent	Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.	Afferent Neurons,Afferent Neuron,Neuron, Afferent
D000161	Acoustic Stimulation	Use of sound to elicit a response in the nervous system.	Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001306	Auditory Pathways	NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX.	Auditory Pathway,Pathway, Auditory,Pathways, Auditory
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D016057	Evoked Potentials, Auditory, Brain Stem	Electrical waves in the CEREBRAL CORTEX generated by BRAIN STEM structures in response to auditory click stimuli. These are found to be abnormal in many patients with CEREBELLOPONTINE ANGLE lesions, MULTIPLE SCLEROSIS, or other DEMYELINATING DISEASES.	Acoustic Evoked Brain Stem Potentials,Auditory Brain Stem Evoked Responses,Brain Stem Auditory Evoked Potentials,Evoked Responses, Auditory, Brain Stem,Acoustic Evoked Brain Stem Potential,Acoustic Evoked Brainstem Potential,Acoustic Evoked Brainstem Potentials,Auditory Brain Stem Evoked Response,Auditory Brain Stem Response,Auditory Brain Stem Responses,Auditory Brainstem Evoked Response,Auditory Brainstem Evoked Responses,Auditory Brainstem Responses,Brain Stem Auditory Evoked Potential,Brainstem Auditory Evoked Potential,Brainstem Auditory Evoked Potentials,Evoked Potential, Auditory, Brainstem,Evoked Potentials, Auditory, Brainstem,Evoked Response, Auditory, Brain Stem,Evoked Response, Auditory, Brainstem,Evoked Responses, Auditory, Brainstem,Auditory Brainstem Response,Brainstem Response, Auditory,Brainstem Responses, Auditory,Response, Auditory Brainstem,Responses, Auditory Brainstem