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In 4 patients with a T-tube the biliary excretion of digoxin was measured for 48 hours. One patient a single intravenous bolus of 0.6 mg digoxin, while the other 3 patients were on maintenance therapy with 0.4 mg digoxin/day. From the single dose a total of 8.8% and 9.2% were excreted with the bile within 24 and 36 hours respectively. During steady-state the daily excreted amount varied between 2 and 10% of the dose in the 3 patients tested. In 2 normal volunteers the effect of the intraluminal binding agent cholestyramine on the pharmacokinetics of digoxin was investigated. The cross-over experiment did not exhibit any differences in the plasma level time profiles. These results indicate that minor amounts of digoxin are excreted with the bile which could contribute only to an insignificant enterohepatic cycling.
U Klotz, and
K H Antonin
April 1976,
Clinical pharmacology and therapeutics,
U Klotz, and
K H Antonin
January 1973,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
U Klotz, and
K H Antonin
June 1987,
European journal of clinical investigation,
U Klotz, and
K H Antonin
January 1973,
Clinical science,
U Klotz, and
K H Antonin
January 1992,
European journal of clinical pharmacology,
U Klotz, and
K H Antonin
January 1972,
Journal of pharmaceutical sciences,
U Klotz, and
K H Antonin
September 1975,
British journal of anaesthesia,
U Klotz, and
K H Antonin
January 1979,
Clinical pharmacokinetics,
