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Our objective was to assess the prevalence of autoantibodies in patients with leprosy. Forty-one cases of lepromatous leprosy were studied. For the detection of autoantibodies we used the Elisa technique using the following purified antigens in an Elisa assay: dsDNA, ssDNA, histone, mitochondria, RNA, RNP, SS-A, SS-B, Sm, Scl-70, Anca C, Anca P and the cardiolipin complex. As a "cut off" point we used values shown on previous studies to differentiate normal from elevated values. Antibodies to SS-B, mitochondria and cardiolipin were the most prevalent in our study. Antimitochondrial antibodies distinct from those seen in primary biliary cirrhosis and antiphospholipid antibodies with variable ligand activity to B2GIP are frequent in the sera of leprosy patients.
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
June 1979,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
July 1973,
Lancet (London, England),
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
January 1986,
Indian journal of leprosy,
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
January 1991,
Wiener klinische Wochenschrift,
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
May 1994,
African journal of health sciences,
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
January 1992,
Journal of hygiene, epidemiology, microbiology, and immunology,
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
January 1964,
Archives of dermatology,
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
January 1967,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
April 1974,
Clinical and experimental immunology,
L S Guedes Barbosa, and
B Gilbrut, and
Y Shoenfeld, and
M A Scheinberg
August 1953,
Journal of immunology (Baltimore, Md. : 1950),
