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The effects of platelet-derived growth factor (PDGF)-AA and -BB on 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic (DA) neurons were studied in cultures of dissociated fetal rat mesencephalon. The 6-OHDA lesion (0.3% for 4 h) caused a selective 75% loss of tyrosine hydroxylase (TH)-positive DA neurons. The neuronal death was significantly decreased (to about 25%) by addition of 1, 10 or 30 (but not 0.1) ng/ml of PDGF-BB 24 h prior to the insult. In contrast, treatment with PDGF-AA (30 ng/ml) for 24 h before the lesion or addition of PDGF-BB (30 ng/ml) simultaneously with or 1 h after 6-OHDA did not promote the survival of TH-positive neurons. We conclude that PDGF-BB can counteract 6-OHDA-induced degeneration of mesencephalic DA neurons.
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
September 2016,
Anais da Academia Brasileira de Ciencias,
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
January 1993,
Experimental brain research,
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
November 2003,
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA,
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
December 2011,
Journal of neurochemistry,
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
September 1992,
Neuroscience letters,
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
March 2022,
Molecules (Basel, Switzerland),
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
August 2012,
Archiv der Pharmazie,
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
January 2015,
Neuroreport,
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
August 1990,
Journal of neuroscience research,
K Pietz, and
P Odin, and
K Funa, and
O Lindvall
September 1995,
Proceedings of the National Academy of Sciences of the United States of America,
