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The effects of a 7-day administration of neuromedin B (NMB) and/or (Tyr4, D-Phe12)-bombesin, an NMB-receptor antagonist (NMB-A) on the function of pituitary-adrenocortical axis were investigated in the rat. NMB raised the plasma concentration of aldosterone, without affecting that of ACTH or corticosterone; the simultaneous administration of NMB-A prevented the effect of NMB. Neither NMB nor NMB-A treatments induced significant changes in adenohypophysis and adrenal weights, nor in the average volume of zona glomerulosa and zona reticularis cells. NMB-A administration lowered the volume of zona fasciculata cells, an effect annulled by the concomitant NMB administration. Our results suggest that NMB specifically stimulates aldosterone secretion, and that endogenous NMB or NMB-like peptides exert a tonic stimulating action on the growth of zona fasciculata cells.
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
January 1993,
In vivo (Athens, Greece),
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
April 1992,
Endocrinology,
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
November 1984,
Biochemical and biophysical research communications,
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
July 1992,
Frontiers in neuroendocrinology,
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
April 1974,
The Journal of endocrinology,
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
January 1995,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
July 1974,
The Journal of endocrinology,
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
June 2008,
International journal of molecular medicine,
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
August 1983,
Pharmacology, biochemistry, and behavior,
L K Malendowicz, and
C Macchi, and
G G Nussdorfer, and
M Nowak
January 1998,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
