-transparent.png){kind=logo}
We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10(-10)-10(-7) M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist. These results suggest that BAM cells possess functional CCK receptors of the CCKA-subtype. Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells.
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
January 1998,
Biochemical pharmacology,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
April 1991,
Neurochemical research,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
December 2000,
Brain research,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
March 1996,
Biochemical pharmacology,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
November 1993,
The European journal of neuroscience,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
October 1985,
The Journal of physiology,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
October 2002,
Anesthesia and analgesia,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
January 1999,
The Journal of pharmacology and experimental therapeutics,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
September 2002,
Toxicology and applied pharmacology,
A M Aarnisalo, and
P J Vainio, and
P T Männistö, and
E Vasar, and
R K Tuominen
February 2008,
Acta physiologica (Oxford, England),
