-transparent.png){kind=logo}
We have studied the in vitro effects of neurokinin A (NKA) on anterior pituitary GABA concentration and GABA release from the mediobasal hypothalamus and the neurointermediate lobe of male and ovariectomized female (OVX) rats. NKA significantly decreased the anterior pituitary GABA concentration, while the presence of a specific anti-NKA serum in the incubation medium increased the GABA concentration in this gland. By contrast, NKA did not modify basal or K(+)-evoked GABA release from the mediobasal hypothalamus of male or OVX rats. However, NKA decreased basal and K(+)-evoked GABA release from the neurointermediate lobe. Since GABA inhibits both prolactin (PRL) secretion from the anterior pituitary and the release of several putative PRL-releasing factors from the neurointermediate lobe, the decrease in anterior pituitary GABA concentration and the reduction in tubero-hypophyseal GABAergic activity induced by NKA may contribute to the stimulatory effect of this peptide on PRL secretion.
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
January 1965,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
January 1968,
Archives d'anatomie, d'histologie et d'embryologie normales et experimentales,
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
May 1973,
Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948),
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
January 1986,
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology,
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
January 1984,
Psychoneuroendocrinology,
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
June 1970,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
December 1983,
Minerva medica,
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
April 1980,
Sheng li ke xue jin zhan [Progress in physiology],
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
January 1991,
Experimental brain research,
D Pisera, and
A De Laurentiis, and
B Duvilanski, and
M Lasaga, and
M C Díaz, and
A Seilicovich
January 1990,
Peptides,
