BIOMAT Database Logo BIOMAT Database Logo

Effect of hyperbaric oxygen exposure on pulmonary clearance of 5-hydroxytryptamine. 1977

E R Block, and A B Fisher

Clearance of 5-hydroxytryptamine (5-HT) by the lungs of normal and vitamin E-deficient rats was evaluated following a 60-min exposure to 100% oxygen (O2) at 4 ATA (HBO). After exposure, lungs were isolated, ventilated, and perfused, with a recirculating system used for measurement of 5-HT clearance. Control lungs were obtained from rats exposed to air at 1 ATA. In control normal rats, fractional clearance of 5-HT was 0.78+/-0.03 (mean+/-SE). Following HBO 5-HT clearance was 0.55+/-0.04 (P less than 0.01). In control vitamin E-deficient rats. 5-HT clearance was 0.85+/-0.05 and was decreased to 0.46+/-0.03 (P less than 0.001) following HBO. To evaluate the effect of recovery time after HBO on 5-HT clearance, separate groups of rats were killed at varying intervals post-HBO. In normal rats, 5-HT clearance had returned to control levels by 3-4 after HBO; in vitamin E-deficient rats, clearance remained unchanged 4 h after HBO and was only 74% (P less than 0.001) of control values 24 h post-HBO. These results indicate that depression of pulmonary 5-HT clearance occurs in rats due to hyperoxia and is potentiated by vitamin E deficiency. This represents a reversible alteration of lung function which requires vitamin E for complete recovery.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D010477 Perfusion Treatment process involving the injection of fluid into an organ or tissue. Perfusions
D011312 Pressure A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Pressures
D006931 Hyperbaric Oxygenation The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke. Oxygenation, Hyperbaric,Hyperbaric Oxygen Therapy,Hyperbaric Oxygen Therapies,Hyperbaric Oxygenations,Oxygen Therapies, Hyperbaric,Oxygen Therapy, Hyperbaric,Oxygenations, Hyperbaric,Therapies, Hyperbaric Oxygen,Therapy, Hyperbaric Oxygen
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012701 Serotonin A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator. 5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine
D014811 Vitamin E Deficiency A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181) Deficiency, Vitamin E,Deficiencies, Vitamin E,Vitamin E Deficiencies
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

E R Block, and A B Fisher
Effect of chlorphentermine on the pulmonary clearance of 5-hydroxytryptamine in rabbits in vivo.
January 1983, Pharmacology,
E R Block, and A B Fisher
Hyperbaric oxygenation and brain norepinephrine and 5-hydroxytryptamine: oxygen-pressure interactions.
November 1969, Life sciences,
E R Block, and A B Fisher
Recovery from hyperoxic depression of pulmonary 5-hydroxytryptamine clearance: effect of inspired O2 tension.
January 1978, Lung,
E R Block, and A B Fisher
Effect of prolonged desmethylimipramine administration on the pulmonary clearance of 5-hydroxytryptamine and beta-phenylethylamine in rats.
January 1982, Drug metabolism and disposition: the biological fate of chemicals,
E R Block, and A B Fisher
Effect of hyperbaric exposure on pulmonary functions in hyperbaric chamber inside attendants.
January 2022, Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc,
E R Block, and A B Fisher
Effect of oxygen exposure on lung clearance of amines.
January 1978, Lung,
E R Block, and A B Fisher
The Effects of Short- and Long-Term Exposure to Hyperbaric Oxygen on Nasal Mucociliary Clearance.
March 2017, The Journal of craniofacial surgery,
E R Block, and A B Fisher
The effect of hyperbaric oxygen on pulmonary metastases in C3H mice.
June 1968, Radiology,
E R Block, and A B Fisher
Effect of hyperbaric and normobaric oxygen on pulmonary endothelial cell function.
March 1993, Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc,
E R Block, and A B Fisher
Effects on pulmonary function of daily exposure to dry or humidified hyperbaric oxygen.
June 1997, Respiration physiology,
Copied contents to your clipboard!