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The activities of class I and II alcohol dehydrogenase isoenzymes were examined in the sera of patients with non-alcoholic liver cirrhosis using a fluorometric method. The analysis of these results shows a statistically significant increase (2,5-times) in the activity of class I alcohol dehydrogenase, and no marked differences in the activity of class II in cirrhotic and control patients. The observed increase in total enzyme activity measured using a photometric method was not very high but confirmed the elevation of class I isoenzyme activity. Activities of both classes of alcohol dehydrogenase isoenzymes have a good correlation with aspartate aminotransferase. Class II isoenzyme activity additionally correlates with alkaline phosphatase. These results suggest that serum activity of class I alcohol dehydrogenase is a better indicator of liver cell destruction during non-alcoholic cirrhosis than total enzyme activity, and is comparable with the value of aspartate aminotransferase.
L Chrostek, and
M Szmitkowski
March 1974,
Sovetskaia meditsina,
L Chrostek, and
M Szmitkowski
July 2018,
Anticancer research,
L Chrostek, and
M Szmitkowski
February 2002,
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology,
L Chrostek, and
M Szmitkowski
January 2017,
Bratislavske lekarske listy,
L Chrostek, and
M Szmitkowski
May 1969,
Nature,
L Chrostek, and
M Szmitkowski
December 2021,
Medicina (Kaunas, Lithuania),
L Chrostek, and
M Szmitkowski
April 1990,
Clinical chemistry,
L Chrostek, and
M Szmitkowski
January 2008,
Journal of clinical laboratory analysis,
L Chrostek, and
M Szmitkowski
February 1993,
Hepatology (Baltimore, Md.),
L Chrostek, and
M Szmitkowski
April 1966,
Bollettino della Societa italiana di biologia sperimentale,
