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Lck, a Src family tyrosine kinase, transduces signals important for the development of alphabeta and gammadelta T cells. However, T cell development is only partially compromised in Lck-deficient mice, suggesting that other kinases may also transduce pre-TCR or TCR signals. One candidate is Fyn, a Src kinase coexpressed with Lck in immature and mature T cells. Here we show that T cell development is completely compromised in lck(-/-)fyn(-/-) mice. In addition, we demonstrate that expression of a gain-of-function mutant fyn(T) transgene completely restores production of immature CD4/CD8 double positive thymocytes and gammadelta T cells and improves the representation of CD4 or CD8 single positive thymocytes. These observations reveal that Fyn can subserve some Lck-like functions in T cell development.
T Groves, and
P Smiley, and
M P Cooke, and
K Forbush, and
R M Perlmutter, and
C J Guidos
March 2012,
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C J Guidos
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T Groves, and
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C J Guidos
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T Groves, and
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C J Guidos
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T Groves, and
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T Groves, and
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T Groves, and
P Smiley, and
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September 1979,
Cellular immunology,
