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We established a human tongue cancer (well-differentiated squamous cell carcinoma) xenograft line, LK-1, in nude mice. LK-1 showed logarithmic growth from 5 to 7 weeks after transplantation, and the take rate for 25 generations was 95.0%. We confirmed the expression of cytokeratins 1, 5, 7, 10, 14, 16, 17, 18 and 19, and type I, III, IV and V collagens by electrophoretical and immunohistochemical analyses. Although the amount of type I, IV and V collagens increased gradually from 5 weeks after transplantation, the distribution of type IV collagen was often discontinuous in the cancer basement membrane. From these data we concluded that LK-1 is an excellent model for the investigation of the cell biology of well-differentiated oral squamous cell carcinoma, and for examining the effects of clinical therapies for this disease.
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
January 1999,
Digestion,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
November 2009,
Anticancer research,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
March 1991,
Hiroshima journal of medical sciences,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
June 1980,
Fukushima journal of medical science,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
June 1989,
Human cell,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
May 1984,
Journal of the National Cancer Institute,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
March 2016,
Head & neck,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
February 2016,
BMC cancer,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
January 1988,
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology,
I Tamura, and
T Sakaki, and
R Shirasu, and
M Wato, and
A Tanaka, and
S Aoki, and
T Sakaki
September 1999,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
