-transparent.png){kind=logo}
Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 microg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 microg/mL) are described. The patients had received several courses of ciprofloxacin. These MICs represent a decrease in ciprofloxacin susceptibility of 200-3200 times. Molecular epidemiologic methods demonstrated that 2 patients were chronically colonized by their own ciprofloxacin-resistant strains for > or = 15-17 months. Three strains showed simultaneous resistance to ampicillin and chloramphenicol by enzyme inactivation, and 2 had ampicillin resistance without beta-lactamase activity. These data suggest that the emergence and long-term persistence of ciprofloxacin-resistant H. influenzae in patients with cystic fibrosis can be a consequence of antibiotic treatment.
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
October 1969,
Lancet (London, England),
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
August 1969,
Lancet (London, England),
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
July 1984,
Acta paediatrica Scandinavica,
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
August 1983,
American journal of diseases of children (1960),
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
June 1988,
Journal of medical microbiology,
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
January 2016,
British journal of biomedical science,
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
December 2003,
Vaccine,
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
March 1993,
The Annals of pharmacotherapy,
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
June 1988,
The Journal of antimicrobial chemotherapy,
J Campos, and
F Román, and
M Georgiou, and
C García, and
R Gómez-Lus, and
R Cantón, and
H Escobar, and
F Baquero
February 1998,
Antimicrobial agents and chemotherapy,
