BIOMAT Database Logo BIOMAT Database Logo

Lysis of syngeneic tumor B cells by autoreactive cytotoxic T lymphocytes specific for a CD19 antigen-derived synthetic peptide. 1996

E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Department of Immunology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Huis, Amsterdam.

Cytotoxic T lymphocytes (CTL) play an important role in the destruction of immunogenic tumors. A novel category of target antigens for CTL concerns normal differentiation antigens as most clearly demonstrated in human melanoma. In the case of B-cell cancers, differentiation antigens normally expressed on B cells may be useful targets. In this report, we have focused on the murine B-cell differentiation antigens CD19 and CD20. We have identified 18 peptide sequences on the basis of major histocompatibility complex (MHC) class-I binding-motifs as candidates for the induction of autoreactive CTL. Six of the peptides were capable of binding efficiently to either Kb or Db and were subsequently used for in vivo induction of CTL. Vaccination with each of three peptides led to peptide-specific CTL. Two peptides were derived from the mCD20 antigen and one from the mCD19 antigen. CTL specific for the mCD19-derived peptide were also capable of killing a syngeneic B-cell tumor line. Recognition of the peptide as well as the tumor cells was shown to be Kb restricted. This is the first report to show that autoreactive CTL recognizing peptides derived from B-cell-specific differentiation antigens can be generated by vaccination with a synthetic peptide.

UI MeSH Term Description Entries
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D003602 Cytotoxicity, Immunologic The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement. Tumoricidal Activity, Immunologic,Immunologic Cytotoxicity,Immunologic Tumoricidal Activities,Immunologic Tumoricidal Activity,Tumoricidal Activities, Immunologic
D006183 H-2 Antigens The major group of transplantation antigens in the mouse. H2 Antigens,Antigens, H-2,Antigens, H2,H 2 Antigens
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000939 Epitopes Sites on an antigen that interact with specific antibodies. Antigenic Determinant,Antigenic Determinants,Antigenic Specificity,Epitope,Determinant, Antigenic,Determinants, Antigenic,Specificity, Antigenic
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D013602 T-Lymphocytes, Cytotoxic Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2. Cell-Mediated Lympholytic Cells,Cytotoxic T Cells,Cytotoxic T Lymphocyte,Cytotoxic T-Lymphocytes,TC1 Cell,TC1 Cells,TC2 Cell,TC2 Cells,Cell Mediated Lympholytic Cells,Cell, Cell-Mediated Lympholytic,Cell, TC1,Cell, TC2,Cell-Mediated Lympholytic Cell,Cytotoxic T Cell,Cytotoxic T Lymphocytes,Cytotoxic T-Lymphocyte,Lymphocyte, Cytotoxic T,Lympholytic Cell, Cell-Mediated,Lympholytic Cells, Cell-Mediated,T Cell, Cytotoxic,T Lymphocyte, Cytotoxic,T Lymphocytes, Cytotoxic,T-Lymphocyte, Cytotoxic
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018941 Antigens, CD19 Differentiation antigens expressed on B-lymphocytes and B-cell precursors. They are involved in regulation of B-cell proliferation. CD19 Antigens,B Cell Antigen CD19,CD19 Antigen,Antigen, CD19

Related Publications

E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Lysis of enucleated tumor cells with allogeneic and syngeneic cytotoxic thymus-derived lymphocytes.
August 1979, European journal of immunology,
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Lysis of MYCN-amplified neuroblastoma cells by MYCN peptide-specific cytotoxic T lymphocytes.
April 2000, Cancer research,
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Targeting cytotoxic T cells to antigen-specific B lymphocytes.
March 1987, European journal of immunology,
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Specific induction of syngeneic cytotoxic T lymphocytes by solubilized tumor antigen: fractionation of the specific R-MuLV-induced leukemia antigen.
July 1980, Journal of immunology (Baltimore, Md. : 1950),
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Recognition of prostate tumor cells by cytotoxic T lymphocytes specific for prostate-specific membrane antigen.
October 2002, Cancer research,
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
[Tumor specific antigen and cytotoxic T lymphocytes].
April 2005, Nihon rinsho. Japanese journal of clinical medicine,
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Delayed kinetics of tumor necrosis factor-mediated bystander lysis by peptide-specific CD8+ cytotoxic T lymphocytes.
December 1998, European journal of immunology,
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Generation of antigen-specific cytotoxic T lymphocytes with activated B cells.
January 2017, Cytotherapy,
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Activation of autoreactive T-lymphocytes by cultured syngeneic glomerular mesangial cells.
March 1994, Kidney international,
E Hooijberg, and M J Visseren, and P C van den Berk, and A P Jellema, and P Romeijn, and J J Sein, and E I van der Voort, and A Hekman, and F Ossendorp, and C J Melief
Cytokines required for induction of histocompatibility leukocyte antigen-class I-restricted and tumor-specific cytotoxic T lymphocytes by a SART1-derived peptide.
September 1999, Japanese journal of cancer research : Gann,
Copied contents to your clipboard!