BIOMAT Database Logo BIOMAT Database Logo

Indeterminate leprosy: a seroimmunological and histochemical evaluation. 1994

B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Laboratory Division, Central Leprosy Teaching and Research Institute, Tamil Nadu, S. India.

An effort was made to differentiate indeterminate (IND) leprosy from other types of the paucibacillary (PB) group of leprosy and to identify among indeterminate leprosy cases those which may evolve to multibacillary (MB) leprosy, using serological, immunological and histochemical parameters. A total of 92 untreated, histologically classified (TT-19, BT-30, IND-32) patients, including 11 cases diagnosed as nonspecific dermatitis (NSD), which were clinically strongly suspected to be leprotic, were screened for antibodies against PGL-I, 35-kDa and LAM antigens. Lepromin tests and antigen demonstration in tissue by indirect immunoperoxidase staining were also carried out. Though a qualitative analysis did not differentiate, a quantitative analysis in terms of a cumulative index (CI) showed a higher antibody level amongst the indeterminate group of patients than the other groups included in PB leprosy. Also, the lepromin negative indeterminate group patients showed a higher CI than the lepromin positive cases, indicating that perhaps these may be the cases which may develop into MB leprosy. Thus, the semiquantification of antibody levels in the form of a CI may be a useful parameter to predict the possible evolution of a given case of indeterminate leprosy. Interestingly 64% of NSD cases had either antigen or antibody which indicated that they were probably cases of leprosy.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007918 Leprosy A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid. Hansen's Disease,Hansen Disease
D009166 Mycobacterium leprae A species of gram-positive, aerobic bacteria that causes LEPROSY in man. Its organisms are generally arranged in clumps, rounded masses, or in groups of bacilli side by side.
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000942 Antigens, Bacterial Substances elaborated by bacteria that have antigenic activity. Bacterial Antigen,Bacterial Antigens,Antigen, Bacterial
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D012698 Serologic Tests Diagnostic procedures involving immunoglobulin reactions. Serodiagnosis,Serologic Test,Serological Tests,Test, Serologic,Tests, Serologic,Serodiagnoses,Serological Test,Test, Serological,Tests, Serological
D015439 Leprosy, Borderline A form of LEPROSY in which there are clinical manifestations of both principal types (lepromatous and tuberculoid). The disease may shift toward one of these two polar or principal forms. Leprosy, Dimorphous,Borderline Leprosies,Borderline Leprosy,Dimorphous Leprosies,Dimorphous Leprosy,Leprosies, Borderline,Leprosies, Dimorphous

Related Publications

B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Indeterminate leprosy: a therapeutic evaluation.
January 1992, Indian journal of leprosy,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Indeterminate leprosy: a clinical and histopathological evaluation.
January 1987, Indian journal of leprosy,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Indeterminate leprosy.
May 1959, Proceedings of the Royal Society of Medicine,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Indeterminate leprosy.
June 1974, Leprosy review,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Indeterminate leprosy.
November 1985, International journal of dermatology,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Indeterminate leprosy: histopathologic and histochemical predictive parameters involved in its possible change to paucibacillary or multibacillary leprosy.
March 1991, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
[Indeterminate leprosy in Japan].
January 1984, Nihon Rai Gakkai zasshi,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Histology of indeterminate leprosy.
June 1982, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Indeterminate leprosy: a new clinical variety.
March 1951, The British journal of dermatology,
B Sekar, and R N Sharma, and D Anandan, and B Vasanthi, and M Jayasheela
Indeterminate leprosy--a valid clinical concept.
June 1982, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
Copied contents to your clipboard!