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OBJECTIVE A cortical gray matter deficit has been found in cross-sectional studies of patients with chronic schizophrenia. The purpose of this study was to examine whether this deficit is present early in the course of illness. METHODS The authors measured cortical gray matter volume on magnetic resonance images acquired within 6 months of onset of illness from 22 patients with first-episode schizophrenia and 51 age-matched comparison subjects from the Stony Brook First Episode Study. RESULTS A significant cortical gray matter deficit and lateral ventricular enlargement were found in schizophrenic patients relative to the comparison group. CONCLUSIONS The presence of the cortical gray matter deficit close to onset of illness supports the role of preexisting structural brain deficits in the genesis of schizophrenia.
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
November 2015,
Psychiatry research,
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
April 2001,
Cerebral cortex (New York, N.Y. : 1991),
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
June 2005,
Cerebral cortex (New York, N.Y. : 1991),
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
February 2014,
Schizophrenia research,
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
February 2023,
Cerebral cortex (New York, N.Y. : 1991),
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
May 2004,
Psychiatry research,
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
February 2010,
Human brain mapping,
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
January 2003,
The American journal of psychiatry,
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
February 2023,
Asian journal of psychiatry,
K O Lim, and
W Tew, and
M Kushner, and
K Chow, and
B Matsumoto, and
L E DeLisi
August 2020,
Schizophrenia research,
