-transparent.png){kind=logo}
Cocaine use has been associated with vasoconstriction and stroke, and several studies have demonstrated that it decreases relative cerebral blood flow (rCBF) in humans. However, rCBF has not been quantitated. We compared 40 mg IV cocaine hydrochloride to placebo effects on absolute rCBF in four cocaine users using 99mTc-HMPAO SPECT with a modified microsphere model for CBF quantitation. Cocaine produced significant decreases in rCBF in all regions studied with a mean decrease of 30% in absolute whole brain blood flow (P = 0.002) which was 3-fold greater than relative blood flow changes.
Related Publications
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
May 1991,
Brain research,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
March 1993,
The American journal of psychiatry,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
July 1992,
The Journal of pharmacology and experimental therapeutics,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
December 1989,
Journal of human hypertension,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
January 1995,
The American journal of physiology,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
October 1994,
The Western journal of medicine,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
June 1995,
Pharmacology,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
February 1983,
Acta physiologica Scandinavica,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
July 1989,
Acta neurologica Scandinavica,
E A Wallace, and
G Wisniewski, and
G Zubal, and
C H vanDyck, and
S E Pfau, and
E O Smith, and
M I Rosen, and
M C Sullivan, and
S W Woods, and
T R Kosten
September 2009,
BMC neuroscience,
